There is a solution out of game for your 5x20 clicks. Use some sort of auto-clicker. I don't this the developers would mind because it does not do anything to game mechanics. You just don't have to click the mouse 100+ times monotonically. It works fine on raids (until you have to heal) and even on quests (mini bosses stop you though) it saves some unnecessary clicks (prolongs precious mouse lifetime).
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