Yes it's true that, in the short term, it makes more sense to break the combo at 50 and start over. However, an analysis of greater skill options reveals that for every 50 after 200 the coin rewards increase at a significant enough rate. By the time you hit 500 combo (which, while not particularly easy, doesn't require much more than a modicum of skill) your cashflow has increased by nontrivial amounts.
tl;dr don't suck, get big combos
Have a lot of enemies coming at you but no Tesla energy? Holding down the mouse button is inefficient in the long run. Instead, try rapidly clicking the mouse button. It works even when you "run out" of energy, and does enough damage to make even the final boss a piece of cake.
Upvote this if it helps you win!
The flamethrower is the best weapon, btw. Zombies just straight up don't come near you when you have it, and you can use it to block vomitspit. Aim at zombies, make sure they're all on one side of you, and run to exit. Also, lit zombies run away from you. Upvote this, I guess.