Pick greatsword. Prioritize all non-spell related upgrades in the mastery tree (upgrade red soul and experience in the tree first). For rings and bracelet, buy the 1500hp ring and the 2 best two regen bracelets (makes you unburstable and tanky) (Other rings are up to you). You're gonna need to do some farming to get the xp and souls needed to max out to make the final boss easy, so stand at an end of the map so that enemies don't spawn behind you. Face one direction and keep swinging. Periodically walk past enemies to collect blue and red drops. Drop a door to low hp to spawn enemies faster to boost drop rate. Rinse and repeat about 20 times to max out. Good luck!
When you are level 1-5, take points in the mastery where the gem slowly recedes back to the cave. This is the best use of your points since you won't get far spending them elsewhere in the early levels, where the lack of masteries will make passing tough.
Overall, melee weapons are best. Guns have too little ammo, and are much more varied than melee weapons. Upgrade strength. Bladed is better in the long run, but blunt is good for the beginning when it's too early to find the katana or axe.