Power glove + all health/crit upgrades = you cant die. Kill the end boss 1v1 in top left corner without having to use the hacking computers. Tip buy every perk that doesn't have to be equipped right away. It makes the early "hard" levels much easier.
Great great great great game. If you never want to die build this: Golem lightwielder. Build stats in str, stam, int. Make sure you have over 100 resist to cold. I had 115. Then the blue knights do 0 damage to you and instantly replenish all of your mana when they hit you. So you can cast Sanctify a million times. I would walk around the levels with blue knights hitting me the entire time and just killed everything else.
Woot just finished day 101 with a lvl 77 hunter. My party is lvl 85 guardian with auto shotty, lvl 81 ranger with gravity gun, and lvl 90 duelist with revolver. The only thing I bought in the first like 12 levels was chickens, I have 135 right now!