Click fatigue is my only real complaint. A click-drag, fencing, or shift-click type of deal would be a time saver and cut down on the annoying "the game is going to expedite my carpal tunnel syndrome" feeling.
How best to make me never play your game: force me to install a plugin that runs slower than flash, has a larger memory footprint than my browser itself, and has more memory leaks than Minnesota has lakes.
The game is keyboard based, and right-handed at that, yet if you need to retry a level, you have to switch to mouse. You should be able to hit or to retry. Otherwise not so bad.