Fun card game! But one suggestion - Instead of saying "Pass," could you change it so that it says something different every phase? Like "End Attack" or "Finish Discarding" or something like that?
I love the idea of trying something new, but this game completely relies more on chance than anything else. The extra life bar just makes things more difficult- I see no real point to it other than wasting your money. The pace of the game makes things exciting, but I feel like you can't win with skill alone.
I'd like you to expand on this idea with a two button input: Item/Run. One button games are lovable for simplicity, but RPGs are even more lovable for complexity. An inventory of two items is far more strategic than holding a single item. Managing three characters provide for way more strategies than two.
While many people don't really care for story, maybe you could try setting a goal or something? Since it's running, you could race for bounties. Or you're escaping levels upon levels of prison.