The new reagents system is not working and unreasonable. Adding this whole new timegate and then having it not work if the reagent is acquired while AFK is a step in the wrong direction.
Rogue should not be the second class, because it is a downright terrible one. Without reliable health regeneration, a class whose only defense option is stealing a single card just gets whittled down and dies a littlle over halfway through W1. I cannot unlock any more classes due to getting bad luck on my rogue runs.
We just put easy mode back in. Try that and rogue will probably be a lot easier.