Some of the poop does not go away when you click it at first. I have a theory that it's actually a nugget showing up as a regular thing of poop but I have no way of proving it. Just a bug that should be checked into.
Skip button is bugged, and that's the only way to farm late game so you can get the Mad Scientist award. ~20% of the time it crashes the game. Other than that, great game.
I beat level E in 83.85 seconds... But instead of improving that to 60 or something, I decided to refine on the others. Turned out to be much easier. 10 minutes to shave off another 20 seconds. It took me 3 hours to beat level E.
Should also be noted that it's most likely the money that's overflowing. Further estimation yields that an upgrade at that point would cost 3.4449 * 10^307. The amount of money I had at that point was 1.78 * 10^308. The hack was that each time you would buy something, it would instead add it to your money total. 2^1024 is ~ 1.7976 * 10^308. Also recommend capping at Lv. 1000 just for aesthetic appeal, on top of it being highly unrealistic for anything past that. You can no longer tell how much things even cost. How much money you even have is lost around Lv. 400. I would recommend putting higher abbreviations after octillion (Scientific Notation would be easier).
Playing a hacked version of the game, I have the game overflowing the power of the blacksmith when you attempt to upgrade at a certain point and crashing the game. This is at 2.52x idle power, 3x active power, and 1797% efficiency. This is effectively the max you can upgrade your blacksmith, putting the base power at ~3.2781 * 10^99. As a comparison, 2^331 is ~4.3745 * 10^99. I'm not sure if it's the money overflowing or the power, but something causes the game to crash, and this is when auto-clicks no longer touch Hellstone Lv. 1164. In order to reach Lv. 2237, you must do so via. multipliers.
Hellstone's stats are calculated each time you go to a new level. To calculate Hellstone's stats at any particular level, use this equation, where "n" equals the level: http://pastebin.com/vM49ptJN Do note, however, that it doesn't store the decimal, it rounds it (and I mean the "ones" decimal, not the decimal at the billions, quintillions, or octillions), so the farther forward you go, the less accurate it becomes.
For anyone wondering, Octillion is the highest "abbreviation" the game has and everything except Upgrade Blacksmith and the materials max out (at least, at any reasonable point). Everything maxes out at: (Blacksmith Skill - 130%) (Blacksmith Expertise - Lv. 10) (Blacksmith Efficiency - 50%) (Gem Waster - 454) (Manual Click Power - 7600%) (Gem Finder - 18%) (Auto Click Power - 4050%) (Auto Click Faster - 13.51/s) (Idle Power - 100%)
That's because you're letting it overheat. If you let the bar where the clip size is get past half, it slows to about 1/3 of its firing rate. Let it cool off and fire in bursts.
(Sorry about the spamming, but this is the last thing I have to say.) All and all, this comes down to the RNG in the game. You can do this from any country, but it works best in places that have both an airport and a shipyard. The smaller the population, the better. That's why it spreads the fastest from Greenland. I've gotten it to work in Cuba, Australia, Greenland, New Zealand, Mexico, Argentina, India, Indonesia, Madagascar, and West Europe. I've started in Madagascar 8 times and only gotten every country from it once. Ships don't like to even leave there, meaning the disease likes to stay in that country until day 25. Once you get down a method that works, it turns all into luck.
Also, don't give up if Madagascar closes its shipyard. Countries can still be infected through a closed shipyard for about 2 days. Drug resistances are vital for both infecting faster and killing faster. Pulmonary Edema does almost nothing - get it absolutely last. Don't get transmissions ever. They trigger closures and if you do it after closures are happening every country will start handing out masks, bottled water, etc. Don't get tier 4. It's not worth it.
Pick virus. Start in Greenland*, Cuba, Australia, or New Zealand. Your starting symptom should either be Coughing or Sneezing* and your only trait should be Durable. Buy resistances 1-1-1-4 in any order. They just have to get there. Once every country is infected with at least one person, evolve Coughing and Vomiting. Wait until about half the world is infected. This is to prevent your disease from dying off with its victims. Now unlock Tier 2 and 3 and evolve Diarrhea, Dementia, Hemorrhaging, Hypersensitivity, Ataxia, Depression. Get anything else you like, it doesn't matter too much.
*Preferred.
Don't listen to other walkthroughs. They don't work. Don't start in Madagascar. Your disease has a very hard time getting OUT of there.
Start as a virus on any island, India, China, Middle East, or South Africa. Preferably Australia. Make sure the starting symptom it gives you is either Sneezing or Coughing and you are durable. Buy either Sneezing or Coughing (whichever one it didn't give you). The starting country should be the first one to close something (usually something like schools). Once it closes something, devolve coughing. Wait for every country to get infected with at least one person. Buy Fever, Vomiting, Diarrhea, Dementia, and every tier 3 symptom. If you don't have enough, leave out Depression, Ataxia, and Kidney Failure (in that order). If you have some left over, buy Nausea, Sweating, Coughing, Fatigue, and Pulmonary Edema (in that order). Hope that they die fast enough to kill everyone in 100 days. All countries should be infected by day 20, all countries should be bright red by day 30, and half the world should be dead by day 40.
Chilling Crypt is OP. If it freezes Ninjas, they won't use the smoke bomb, allowing all your towers to destroy the Ninja Champion simultaneously (provided the first shot freezes it).
Meteor is OP too. Makes the brilliant medals possible.