The stuttering makes it completely impossible for me to get to 1100 on hard... but I see you're already aware and are working on it for the next game. But I have one more issue... I got to an area once with lots of splits and curves, and a part of an obstacle in a nearby tube stuck through and completely blocked the way.
Great game, by the way. It reminds me of an old favorite (3d missile something?) You should have a talk with Nintendo about padding games with loads of transitions. They would learn a lot.
kmoney, it's probably the way your keyboard is wired, try switching from 1234 scheme to ASDF (it's along with the quality and sfx options.) If that doesn't work, get a new keyboard or play a different game.
For those who say the sedate button doesn't help, you're supposed to click it and insert the syringe into one of those tiny boxes that appears in the lower middle of the screen.
Good game, needs badges, and too easy. Fun though. 4/5.
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ALT+ENTER should work too :)