I'm not sure about anybody else, but until today, I had a helluva time playing on any mode BUT Easy.
I advise you get a Warrior (Front middle, most targeted spot), Rogue (On one of the sides) Barbarian (Other side) and Cleric (In the back)
Get as much armor for the warrior as possible, and at Lv 2, get Shield Wall. This will help greatly for the next big fight. Give your Barbarian as much health drain/life steal items as possible. He/she will benefit the most. If you ever come across a dexterity/strength orb, use it for the Rogue. Your Rogue needs that.
Keep the Cleric in the back, making sure you have a good Censer for him/her.
If you're fighting Orcs, KILL THE TROLLS. Those things hurt much more than any other enemies.
Surviving is more important than getting that 6x combo. Packing the armor is a much more valuable tool than the auto-turret, or the decoy grenade. Make sure to prioritize your targets; Don't let too many purples live. You'll get slowed to oblivion.