I'm close to the end now (level 150) after playing about 5 weeks. I haven't used any Kreds.
Longer runs are to inefficient in my opinion. Currently I get the most points/minute after about 3 minutes into the run at level 131(18.7b points at 6.23b/minute). After ~28 minutes at level 135(40.1b points at 1.43b/minute) I can overload. After about 8 hours I get to level 142(152b points at 0.32b/minute). I get more points in 4x30 minute runs than in 1x8 hour run.
The level 100 unlock (Bombardier) makes Gunners completely useless. So all the Talent Points I put in there are wasted. It would have been better to just upgrade the Cube.
In it's current state it would take a few months to complete for people who expect an idle game where they can just let it run for hours but for those who can play at least a little bit active, it can be enjoyable.