Tips for getting high combos: (1) Avoid damage cards. Drain them out with other cards by using Sketching and Quick Sketching. Once you find Sketching, you can pass turns until you see another Sketching card to duplicate it. The first enemy is harmless as long as you don't hurt it first. (2) Manipulate your card selection for combos. Curiosity, Inspiration, Muse, and Apple Pie are all very helpful because they add Ideas and draw new cards. Get into a flow of getting Ideas, then using them on card refills. (3) Get lots of Meditation cards. Because Snack Time costs 15 idea points, Meditation is 10 Ideas cheaper, effectively giving you 10 extra Ideas to work with. (4) Use the hotkeys. The current all-time record was before the hotkey update, and I accidentally ended it early (before 50,000) by clicking the "Pass Turn" button. It's faster, too.