Shotgun with all upgrades, includes the gauss upgrade, is the best weapon.
And if u hold the left mousebutton and then switch to shotgun u dont have to click again and again.
When i switched from Flamethrower to handgun, it shoots fast as the flamethrower and sometimes u shoot instead of 30, 160 projectiles.
But this game needs an End, and some Badges.
Stopped game after 6.500 Kills with all Upgrades and playing about 2,5 Hours :)