I feel sad not because of the game's meanings, but because how cute Leigh looks! seriously! all the "bad" option (if the game is really a metaphor of drug addiction/self mutilation is the good option) make feel sad because of her look.
Guys, she's actually a representation of drugs! when he said he met her when he's a teenager that means he start taking drugs. "Wrapped herself around my arm" means drug addiction. The hospital scene is NOT self mutilation, it's a REPRESENTATION of drug withdrawal (the effect when you suddenly stop taking addictive drug). When he stays with leigh that means he keep taking drugs. I'm just giving my opinion so your mileage may vary.
We'll see what we can do. Thanks for the feedback!