Even when just starting the game, is sometimes very unresponsive. Mouse over an upgrade button or even the save file, and it takes a few seconds to highlight / respond to a click. Holding the mouse key down for a full second is often necessary to get a successful click on a UI element. I see a lot of loading URLs pop up in the browser while game is running - might be blocking the UI thread??
A manual save would be nice. Sometimes I quit soon after collecting some raid loot or switching to an offline farming loadout, but when I next start the game my loot/loadout is gone.