I cheated at Run'n'Gun. One of my friends did the ASD buttons while I easily used both hands to pass that left right left right left right left right up part XD
I'll first explain what it was in full detail. Clicking the upgrade itself wouldn't trigger it. Clicking "continue" will. Trigger what? A screamer. A color-inverted angry face with sharp teeth yelling "YEEEEEAAAAHHHH!!!!!!" So first step is to mute the volume to reduce the scream, so now to do something avoid the face. Buy it first so you won't have to worry about forgetting it. Get something big enough to cover the screen like a notebook. Click continue then put the notebook or something else to cover it up. Wait for about 60 seconds. You can constantly peek at the screen to see if you're curious. But do that at your own risk. But actually the best solution is to suck up the face and mute the sound. Or run like hell. OK, I lied. That's not even close to best. The best way is to get someone else to click it. It's mean but you can explain what it is beforehand. You can let him/her do it for you if he/she has experience with screamers.
Think of this as a Zombie Apocalypse game with extra twists. For example, all the races atempt to destroy each other, and you're the most powerful Demons. Other teams will be Zombies, Humans, Animals, Aliens and such. It helps. Or play your game with the Highschool of the Dead opening. Just make the game look and sound as epic as possible, this way you can work up your confidence to beat it.