I don't know if it's just me, but when you start in a region that you know isn't gonna win you the impossible badge, selecting "new game", then "realistic", then "disease class" and finally "disease name" feels like it takes an age and a half with all that damned menu fade time. And combine that with the fact that you're gonna have to try for hours to get the badge...well...let's just say that I don't like the starting menu format. :P
One problem: the game screen is too tall. As a result, moving your mouse pointer over the opponent's item in the top right corner leaves you with not very much room to see its description in the bottom left corner. Other than that, so far so good. =)