There is some heavy inbalance:
1) It is far easier to obtain an epic creature from a draw than to evolve it from its rare predecessor.
2) I came along to region 11 quite okay. not easy but okay. From region 12 on i start dying after the first encounter. no experience, nothing. so its replay. but to go where? I won't get materials to evolve my rare creatures until i manage region 12. To develop them until lvl 100 is just ridiculuous and even then - they are weak compared to the epics.
there may be a chance of killing humanity with bacteria:
I started in Cuba with Coughing and heat resistance. I added the basic resistances withouth drugs. and moisture II.
after infection of a 2nd country i sold coughing and bought waterborn transmission. countries shutted down very late and i bought drug resistances and then as many deadly traits as possible.
result: peru/argentina survived (I guess per chance) every one else got killed after 110 days.