@jesse
upgrade bomb resist hat and chest, equip one on each male, then get ice resist (hairpiece, staff, and chest) on natalie. you don't need more than rank three on any of them except maybe natalie's chest.
put the poison sword and the snipe gun on, then get a load of pineapples. use nettle until the mammoth is tier9 poisoned while using girl and second guy to heal (spells or pineapples). after the poison is at 9 deal with his adds as you see fit while keeping healed, letting the poison eat him. After you nail the healers he melts. Alternatively you can kill heals before stacking poison, but he dies faster if you let them live (note: other than now healers should be primary target. this is a rare exception.)