The main problem is that the dodge rates get pretty ridiculous. Fights get really tedious just swinging at each other for like 10 minutes waiting for the RNG to smile on someone :/
The one silly thing about this game is having to grab the random flask on the bartender's shelf, even though you specifically had to buy most of your other stuff that wasn't just on the road.
The bosses have way the hell too many hit points. This doesn't make the game harder at all, just a lot more tedious while you chip away their damage sponge by repeating one very simple evasion pattern for like six minutes.
For those going for the 1000x kill chain platinum, stand in the middle and DON'T get the pixels to level up. When you level up eventually just from pixels that fly into you as the bad guy explodes, go for spread and sweep out a circle around you for free kills.
Good at first, but the last few levels get really tedious. The longest point a to point B path loaded with dudes with a bazillion hit points but no tricks more interesting than a single aimed shot doesn't make the game harder, just boring.
This game really, REALLY needs an option to set the quality low. Between the huge levels, the constant zooming, and the rotation, it's really not processor-friendly.
Do small wavy motions when on straightaways to maintain your speed, and when you have to climb do so in small stairsteps. You gain more speed going down a few pixels than you lose going up several.
The only problem is around 13,000 you start getting blind jumps -- the track ends before you can see the next piece and you have to just guess. If the next piece is at maximum jump distance, or a tiny piece at midrange, it's basically pure luck whether or not you make it.
The problem is that once you beat the game and get into the Hard modes, Hard 9 and all Epic levels feature units that can basically twoshot your entire army until you grind Hard 2 for several hours to upgrade heroes and get a titan or two.