Problem: I've killed the boss Mother Sobo, but I haven't been able to progress past that. I've been given no new quests since the "Sharp Objects and Voodoo" quest, and I haven't been able to move on from there. Solutions, anyone?
Easy Exp Tip: When you get the option to make all the monsters Armored, do it. Put all the modifiers on their max setting. Level up the Focus, Forge, Construction, and Replenish skills as high as you can get them. The Forge and Focus skills are the most important, because they respectively lower a gem's mana cost and start you off with more mana. In the pre-game area where you can view the map before starting the waves, build walls that force all of the enemies to come through as narrow a point as possible. Line up this passage with towers, and stack high-level gems first, working backward to lower-level gems. After enough time, it's easy and quite common to have six towers all with (at least) level 5 gems. I usually have two or three level 6 gems in there, too.
Because Armored monsters tend to be slower than Swarm and normal monsters, a hallway 2 or 3 towers long with mid-high level gems will destroy the monsters, easily gaining high amounts of exp.
Quick Tip: A destroyed enemy leaves a mark on the ground. By about the third or fourth wave, there should be a pretty consistent line where your defenders kill the aliens. How does this help? Wherever the marks on the ground get past the line, add another defender pointing in that direction. If you can manage to kill all the aliens at the line without letting any past, you've got it good for the rest of the level.