I can't take it anymore. Clicks are not accurate enough and take too long to string time bonuses together for any length of time. Game still ends while there are moves available.
I will second Draco18s comments. I've noticed that it is sometimes difficult to click on neighboring aliens when stringing together runs. In addition, I have seen a few instances where I have planned out subsequent pairs, only to have the game tell me that there are no more matches.