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Defensive builds are broken. Get nova and fortify, nothing else is needed, just focus on those two and you literally cannot die. If you want to farm and have a spare computer, just start running with that build, you don't need any upgrades but building up nova and maybe life reduction stuff (darkness and nature) with auto skip and nothing can kill you, at least not for a long time.
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So I finally reached far enough in Hard to move to Tier 2... Did a few extra waves after Tier 2, saved it, left it alone for a few days while the factory accumulated points for me... and I KNOW I SAVED TO CLOUD! Why is it even the cloud takes me to before Wave 1000 Hard?
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I like the game concept and how much content there is. There doesn't seem to be much of an end to how much you can upgrade things.