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I can’t really give you a deck or anything, but some tips:
- Banish is very helpful, as it disables his events and prevents healing from Iso-man’s ally card
- Little Suzie Antihero, if you have her, really helps. She banishes an ally on play, and on deplete she gets rid of a whole bunch of events
- Packing as many allies as possible can really help. This avoids chit-chat from damaging or healing.
But other than that, it also just depends on what you’ve got to work with. I don’t always win against him myself, sometimes it depends on luck as well (multiple chit-chats will kill anyone)