The allocation of skill points is entirely subjective, depending on what character you’re rolling,
but I would recommend, for any character, a decent speech and medicine.
Speech opens up a broad spectrum of dialogue choices, and medicine grants you more health from stimpaks.
As for weapons; it depends on whether you’re going for lead-spitters or laserweapons. Or melee. Or Unarmed.
The best place to visit to check these things out, is the fallout wiki.