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I haven't seen this explicitly stated before, so here it is:
If it's round 2
and you're assigning combat damage
Assign as much damage as possible to your first four cards.
If there's enough damage that some of your cards will have to be be knocked out,
knock out your first four cards rather than your last four cards.
Of course, you should avoid knocking out resource cards and high culture cards.
Just in case people don't know why, a card can't be played at start of round 2 and round 3. Hence those first 4 cards won't show again until round 4 and you lessen your chance of being dealt a gravestone in round 3 and will have higher health cards in round 3.
It's not a hard rule, sometimes certain war cards are worth keeping alive for round 4, even though as Rast mentioned, economy cards and culture cards will give the most direct benefit post war/in future rounds.