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My strategy:
prepare a powerful 100-100-100 potion for emergeny cases. save.
Then create a 25-25-25-potion-red fire not this easy to control, but no enemy, but giant will be able to pass it alive.
30-25-25 is blue fire, seems to be more effective to red spiders and white skeletons.(But it doesnt really matter, they won't even pass 25-25-25.
When you hear a with laughing, increase the blue factor to 50-80, when you detonate the potion close to the witch, it will die immediately.
When a giant appears, 25-25-25 is also enough, but if you use to miss, better increase it a little to have bigger range, with this tactic, 10 giants would be no problem(just a problem of lag.)
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OMFG I FOUND THE BEST (fire) COMBINATION!!! 2 , 1 , 3, its just kinda a small wall of fire but can kill a white skeleton in 1 second
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OMG 100 - 50 - 0 you will not be dissapointed, aim just above what you wanna kill, it will pepper the enemy below with great dammage, wipe out in 2 seconds
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44-44-55 is a good potion for later in the game, it spreads everywhere and kills fast. Plus, spikes are the most valuable upgrade in my opinion.
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you know, just one potion type ain't good enough.. combine sticky goo and flame and watch the lag. (example: 15,0,20.. then 15,15,20)
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17-17-0 = ownage
Try shooting it in middle and clicking right after detonated.
Guarantee if you did it right no ground enemies left.