compel

There's basically no way to discern between melee and ranged enemies before the smoke cloud clears, which makes it pretty much blind luck because you have to already be moving in the right direction to survive the first couple moments.

there's too many rooms before the boss, and you need to get 1 hit to die...

Interesting concept, but there's too few enemy types to keep me engaged long enough to push past the first handful of deaths. Also, as Pykrete said, there's no way to distinguish the enemies in the first few moments, making it feel like blind luck when you do guess the right room layout.

Speaking of room layout, I did actually like the random room generation because not every run was the same. However, they're very similar due to the aforementioned lack of enemy variation.