Seems to be a bit of a bug with higher level gear, level 68 rare (blue) main hand dagger +478 agility, level 71 epic (purple) main hand dagger +441 agility
While I would be a fan of having the option of one button per area -OR- arrow keys, all it takes is waiting til you're focused and calm. After that I just let my eyes slightly out of focus, somehow that helps me keep all of the dots in view for me.
Don't lag ;).
Aeronautics, earrings, aspiring, words like this are helpful near the end when you're about to get overrun. Just pop in the word of the day and then throw these guys out along with variations of them and things can turn in your favor.