This method has worked on realistic/relaxed so far even though I started in Canada! Parasite>Sell any symptoms unless it comes with fever>heat 1>cold 1>moisture 1>waterborne>drug 1>drug 2 ~lots of patience~ Pick head/cold/moisture 2 if the last few regions need infecting are all one of those. Once you have every region infected, start buying symptoms. They'll start researching a vaccine so buy drug 3 and 4 and continue on to infect/kill everyone :)
It's so funny when theres just one lone ship out there when all the ports are closed, who's aboard?