I'm really pissed about the miasma chalices, they're a one go thing, so you have to read the walkthrough ahead of time to make sure you know they disappear after defeating the boss of the temples. If you saved over that, then it's hours of back up and you have no chance of getting the impossible badge - so go ahead and read the walkthrough, take away the challenge of figuring it out yourself or doing it your way, so you have a chance at the impossible badge.
To beat the security guard, have null air, morality block and some way to poison it (you can buy bottles at the lizards shop). Then just wait it out (keep recasting, healing anyone dead etc.)
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