I feel like near end game there's not really any reason to go past level 100 because the 25% chance of getting 1 time cube from each boss is not near worth getting the 10 time cubes at 100 and resetting immediately
It may seem obvious to most but getting an autoclicker will help alot and save you from getting carpel tunnel. Keep track of where exactly the rainbow ball comes rolling down the screen. Place a small sticky note paper on the location, so when you go afk during bosses you can make sure to get the extra gold. The best upgrades for your team come at x50 and x00. If you're stuck on a boss try to get those first. Use the "6" ability right when you get to a rainbow level for massive gold
I got 1 day, 21 hours by doing the following (in order): 5 in research, 5 in cash, 3 in reload/aim alternatively, then put 5 in reload and leave aim at 3. Then 5 in plant and start growing. Don't put any points in health (try not to get hit). My strategy for killing was to wait until the monsters are really close to me and then kill them as quick as possible and immediately afterwards hit down and shift at the same time to reload and keep upgrading. Get the sniper rifle when you have $650 and the raygun when you have $7000.
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Just for future reference, after arena 100 there is a 25% chance a boss (including min-bosses) will have a time cube.