I think the most hated ability in this game is lobotomizer, makes the game stupid: you play a virus to destroy it, lobotomized; you take an othyugh to devour it, lobotomized. You just can play using brute force
or with lots of luck
The only fail I've seen in the game is that
a weird mutant creature hitten with reverse time becomes as it "should" be: it looses it's ability or extra hp or damage