It's not impossible, you just have to realize that you only need two of the best fuel tanks to reach the last boss from the final checkpoint. And when you stack the damage enhancers, the tripe missile launchers aren't worth much. Make most of your first two rows triple guns, stack as many of the shield rechargers as you can, put three, maybe four of the max level shield items and then as many damage enhancers as you can fit while leaving space for the required two fuel canisters
 "Galaxy Siege"){kind=icon}