I think you should be able to assign the bots to hotkeys for easier control, and use wasd and arrow keys (two bots at a time) for better control. I don't mind harder difficulties if I get better control.
Ahh, Bullet Heaven? Nice calculations. After all...Positive (Heaven) + Negative (Hell) = Negative (Bullet Hell). Negative (Hell) + Negative (Hell) = Positive (Heaven). So if you named it bullet hell, it'd be easy right?
I could have done Challenge 4 if it wasn't for the stuffed up AI. For some reason, I command it to go somewhere, it goes there THEN immediately goes into wander. So annoying.
Final Hour is easy. Use cerberus + (19 weight I think armor?), then a 15 weight armor or one less + a pulse I think it was...or if any extra weight put cerberus. Then just gang on the scream shard, then cer. Easy.
Wow, I was surprised but the simplicity of this yet it's awful. Awfully great that is! 4/5, hope you make a 3rd one! Just add some more upgrades, more enemy types, perhaps something more then just dragging your mouse/clicking (virus skills?), maybe 2 campaigns where one you play as virus, infecting, one you play as immune system, where you had cooldowns and can summon white cells, get antibiotics and new enemies as upgrades, upgrade durability of white cells etc.