speed is severely worse, if you level up the speed, you are set back a huge amount because the worth gets 1.5* but the waiting time becomes 40* longer. in the old version the setback was less because worth was increased by 10*. now it takes me about 20 minutes to get back when I accidentally click the level button when I didn't mean to. prestiging also isn't possible then because it is based on the amount you have at that moment so I have to really work myself all the way back up. also progression has really halted compared to before.
the top left and bottom right skill are very useful, the bottom left and top right are quite useless. Automatic collect at max gives you more pixels than manual collect, so get that to max as soon as possible (I still started with the bonuses at 10 and 25 from the top left, so I do not know which of those is better in early game.