I beat easy...
but I never really understood what I was doing... I kinda just built several of each tower in a huge gauntlet... and then just read what he was saying for fun.
But I do think that it would help a lot to introduce each tower one by one... so it would be easier to understand what actually needs to be done.
 "Mini Guns"){kind=icon}
 "Transformice"){kind=icon}
 "The Great War of Prefectures"){kind=icon}
 "Bacteria Tower Defense v.081"){kind=icon}