I'm assuming once you get the hang of the game, it's fairly easy to play, but there's so much to take in, I'm going to have to play through at least 3 times just to understand the controls and what they do xD
From what i've found, all of the buildings have the same items and people and supplies in them as any play through, so if you make a note of what you need and when you'll need it and which buildings have what, it'll be easy to get 5 survivors and easy to beat the game. Personally i love the chainsaw...
 "Rings"){kind=icon}
 "Pandemic: American Swine"){kind=icon}
 "The Last Stand 2"){kind=icon}
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 "Drop Dead"){kind=icon}
 "Excit"){kind=icon}