The major issue I have with this game is not being able to replay previous stages to gain more exp etc. so basically you're screwed if you didn't train enough in previous stages.
After playing this for many hours straight, I ran into a wall in my house thinking that I would be able to keep on going normally. Unfortunately, I lost the level and there was no respawn.
This is why Run 2 tells you not to try it in your home universe.