A strategy that works fairly well against everything but a complete dps overrun tactic is three entropy aliens and one star spirit(in back) Entropy aliens seem to do damage to things that hit them with melee attacks (over-riding any healing effects involved in said attacks), and will tank a decent amount of damage while killing all of the opponent's melee attacks, then the star spirit picks off any ranged attackers.
I just need to find a better ranged attacker with a small enough hitbox to let melee attackers hit the entropy aliens, which is the entire reason I chose the star spirit to begin with.
I've been trying to get to floor 15 with just running to the hole while tanking the damage, and so far I've only been able to get close with a golem/werewolf juggernaut with nudist and dauntless.
Why did I have to do some convoluted puzzles to move the fireplace out of the way when there were steps leading to behind the thing the whole time? lol