Where are you hiring henchmen from when your secret base is on the moon?
Where do the turrets come from? Is there a bunker full of a few million of them?
Why can't you organize missions into a larger campaign/plan (e.g. to kidnap several journalists at roughly the same time)? ... So many questions.
I just fought through this using nothing but the beretta. I'd say the difficulty ramp needs some tweaking.
Also, don't skip the tutorial: I'm sure that swapping weapons is useful.
Got the big boss down to just under 1700 health, but he escaped. I had 4 lives left but he never returned and no further waves did either ... is there no win condition?
Also, I dropped one of the grey guys into the last box and he went to stand in the middle of the rocks, but as far as I can tell nothing every happened because of it. And I couldn't get him back out and up onto a tower.