"And on top of that, I’ve just discovered the joy of plasmid guns! You should try them, jofrezu."
Never use plasmid guns. Always double machine gun and a shield to protect it.
I thought this game was hard at first, but there's a major bug which allows you to change the color of the orbs while the game is paused, so all you have to do is pause the game and change the colors, and 15000 points is easy.