Okay, I killed over 200 guys in the genetics research lab and the door still didn't open. Are you JOKING?! What, are you supposed to kill 1000? 10000? Is there a difficulty level in this game for people who have lives?
Wait a minute, let me get this straight. You have a life bar, but a single hit kills you. Accidentally moving the mouse outside the game window pretty much permanently freezes your guy. And to top it all off, when you die, the game crashes? Oh. My. God. 1/5.
It's too hard to keep the cursor in the tiny little window, and clicking outside the window makes the game go ape. Why does the guy keep picking up empty weapons when I try to use the lead pipe? Why is it that sometimes he can take 50 shots in a row, but other times, a single shot kills you? The only good thing about this game is quitting it. 1/5.
The near-constant screen-shake effect makes it too hard to see what the heck is going on. Maybe that's intentional--maybe it's supposed to be part of the challenge--but I don't like it. Part of the challenge of a game shouldn't be that playing it gives you a headache. Also, the random maps have too much cheese, like unavoidable clusters of boxes right before long gaps. Hitting 5,000 points is mostly a matter of luck.
I like how jumping randomly fails and how your guy randomly falls through solid walkways. That's really fun, especially when it happens at the end of a long level. Oh, I also love the thoughtful and creative level design, but shouldn't you have credited the designer, Mr. Random()? :P 1/5.