this game is very hard but here are a few basic tips.
Don't worry about antidotes on first few runs when you have better guns you can go back for them.
Each level has a set number of antidotes. around 10 or so. you can see the number you have in each level by hitting the back button
after playing this for a few days imo this is a poorly done trimps clone. The trimps clone isn't the bad part, I enjoyed trimps. My problem is with balance and death. throwing thousands upon millions and billions of trimps to die for no reason didn't mater to most of us. but now your putting together a party of 3 and expect us not to care if you destroy them over and over? not going to happen. as far as balance I've hit a wall that can not be over come as far as i can see most of the good upgrades require gold, yet i can't get gold cause i die every time i kill something. yes i can do the 3% upgrades for months and months to over come this but who would find that satisfactory. Not to say some people wont do that. I'm saying i wont. maybe after you update it and smooth out some of the problems i will check it out again.
I've found the optimum way of building is to build a brand new power plant of some type for each energy reliant object you build. For example a sand pit is best built next to either a coal power plant or a windmill. Keep the power plant just high enough to power the object. Steal plant is perfect next to a windmill on the hill behind it. Now think about this for a sec in this world every time you want to build an object it is cheaper to build a new power plant just for the object than to run a few power lines to it.
I've only played this for a few hours so far but a few things you may not be aware of in real life water pipes are underground and power lines are in the air. I can't stress how annoying it is that they can't cross over each other. the game is less a simulation and more a how the hell can i do i set this up with both power and water, or power and road. I like how all the power stations are magically connected but why not just make a 2 unit structure road that has both power and road and a second one with both power and water. one one other note roads, power, and pipes cost exponential more money, that is a serious flaw imo.
The new B M K help some on custom, but i would like to use the quick buttons. simple solution is to put B M K buttons next to the fire button. each button would be a multiplier for the current bar. I'm constantly changing the custom button for the population of my trimps. While now i don't have to add 6 zeroes i still have to change from 5 to 10 to 100. these modifiers would only work with jobs not buying things.
could you add a row multiplier for buying items. for example right now it is 1 10 25 100. Could put in a custom multiplier of say 1000 and it becomes 1000 10000 25000 100000 i know that sounds redundant but i'm constantly changing the custom to do this same thing. Custom works for this but as numbers get higher that row gets more and more useless. this is only for hiring and firing trimps, so maybe you could put it next to fire button.
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It's something that will be addressed by the Prestige System/Idol Shop when it's implemented.